Extramedullary Myeloma
نویسنده
چکیده
Extramedullary myeloma (EMM) is the presence of clonal plasma cells (PCs) outside the bone marrow in a patient with multiple myeloma (MM). EMM can be present at the time of initial diagnosis (primary EMM) or at the time of relapse (secondary EMM) [1]. EMM has an incidence of 7% to 20% at presentation and 6% to 20% during disease progression [2]. Using sensitive imaging techniques including MRI and PET/CT, EMM may be found in up to 30% of MM patients across the overall disease course [3].
منابع مشابه
Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma
Poor outcome of extramedullary disease in multiple myeloma patients and lack of outcome predictors prompt continued search for new markers of the disease. In this report, we show circulating microRNA distinguishing multiple myeloma patients with extramedullary disease from myeloma patients without such manifestation and from healthy donors. MicroRNA-130a was identified by TaqMan Low Density Arr...
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Even in the era of new drugs, multiple myeloma patients with extramedullary relapse have a poor prognosis. Our goal was to analyze the frequency and outcome of extramedullary relapse occurring in relapsed multiple myeloma patients. In total, we analyzed the prognosis of 226 relapsed multiple myeloma patients treated between 2005 and 2008 and evaluated them for presence of extramedullary relapse...
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Extramedullary plasmacytoma occurs in 18% of patients with multiple myeloma. Laryngeal involvement in multiple myeloma is rare, and only a few cases have been reported. We present a case of a 44-year-old women with multiple myeloma who presented with stridor due to a mass involving the larynx which was initially proven to be plasmacytoma on biopsy. She had evidence of multiple myeloma of IgA la...
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Extramedullary disease in plasma cell disorders can occur as a solitary plasmacytoma or can involve multiple sites with vastly different clinical outcomes. The article by Khaliq et al reports an unusual case of solitary extramedullary plasmacytoma (SEP) of the bladder in which the patient had a favorable outcome with lenalidomide/dexamethasone after failing first-line treatment with radiotherap...
متن کاملExtramedullary Plasmacytoma of the Pancreas: Imaging Findings: Case Report
the incidence of extramedullary plasmacytoma is 5% of all plasma-cell neoplasms. The vast majority of extramedullary plasmacytomas present as a tumor secondary to systemic myelomatosis of the bone marrow; extramedullary plasmacytoma involving the pancreas is very rare, and only 19 cases have been reported in the English-language literature (1). A few such reports have described the radiologic f...
متن کاملA Case of Mediastinal Extramedullary Plasmacytoma Associated with Multiple Myeloma
plastic proliferation of plasma cells arising from non-osseous sites, while the neoplastic plasma cells in multiple myeloma patients usually involve the medullary space of bones. Extramedullary plasmacytoma may be primary or secondary to marrow involvement by myeloma. Extramedullary plasmacytoma arising from the mediastinum is known to be extremely rare (1). Herein, we present a rare case of me...
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تاریخ انتشار 2016